SrasV1, 2020, Analysis, bibRecord, 000A71

Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities

Identifieur interne : 000A71 ( 2020/Analysis ); précédent : 000A70; suivant : 000A72

Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities

Auteurs : PENG ZHOU [République populaire de Chine] ; HONGXIA LI [République populaire de Chine] ; HANZHONG WANG [République populaire de Chine] ; Wang Lin-Fa [Australie] ; ZHENGLI SHI [République populaire de Chine]

Source :

Journal of general virology [ 0022-1317 ] ; 2012.

RBID : Pascal:12-0103990

Descripteurs français

Pascal (Inist)
- Coronavirus, Interféron, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Coronavirus, Interferon, Severe acute respiratory syndrome.

Abstract

The ORF3b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has a nuclear localization signal (NLS) at its C terminus and antagonizes interferon (IFN) function by modulating the activity of IFN regulatory factor 3 (IRF3). SARS-like coronaviruses (SL-CoVs) found in bats share an identical genome organization and high sequence identity for most of their gene products. In this study, ORF3b homologues were identified from three bat SL-CoV strains. These ORF3b homologues were C-terminally truncated and lacked the C-terminal NLS of SARS-CoV. IFN antagonist activities analysis demonstrated that one SL-CoV ORF3b still possessed IFN antagonist and IRF3-modulating activities. These results indicate that different ORF3b proteins display different IFN antagonist activities and this function is independent of the protein's nuclear localization, suggesting a potential link between bat SL-CoV ORF3b function and viral pathogenesis.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000074
to stream PascalFrancis, to step Curation: 000913
to stream PascalFrancis, to step Checkpoint: 000069
to stream Main, to step Merge: 002020
to stream Main, to step Curation: 001F94
to stream Main, to step Exploration: 001F94
to stream 2020, to step Extraction: 000A71

Links to Exploration step

Pascal:12-0103990

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities</title>
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<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences</s1>
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<front><div type="abstract" xml:lang="en">The ORF3b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has a nuclear localization signal (NLS) at its C terminus and antagonizes interferon (IFN) function by modulating the activity of IFN regulatory factor 3 (IRF3). SARS-like coronaviruses (SL-CoVs) found in bats share an identical genome organization and high sequence identity for most of their gene products. In this study, ORF3b homologues were identified from three bat SL-CoV strains. These ORF3b homologues were C-terminally truncated and lacked the C-terminal NLS of SARS-CoV. IFN antagonist activities analysis demonstrated that one SL-CoV ORF3b still possessed IFN antagonist and IRF3-modulating activities. These results indicate that different ORF3b proteins display different IFN antagonist activities and this function is independent of the protein's nuclear localization, suggesting a potential link between bat SL-CoV ORF3b function and viral pathogenesis.</div>
</front>
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Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities

Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri